诃子的影响。小鼠小肠生长抑素分泌的研究

摘要

何敏*,赵思琦,郭希燕

目的:研究诃子的药理作用。(TC)及其两种加工产品Rubia cordifolia L. per Terminalia chebula Retz。(RTC)和大戟属fischeriana Steud per Terminalia chebula Retz。(ETC)对小鼠小肠生长抑素细胞分泌活性的影响。方法:选取20日龄SPF级昆明小鼠168只,随机分为7组,分别为对照组(生理盐水,0.1 g/kg)、高TC、RTC、ETC和低TC、RTC、ETC组,给药28 d。用免疫组化方法检测给药7、14、21、28 d后小肠SS细胞的定位和表达情况。结果:生长抑素(SS)蛋白广泛分布于小鼠小肠。免疫反应性从十二指肠到回肠逐渐下降。给药28 d后,高TC组、RTC组、ETC组、低RTC组和ETC组SS免疫反应明显低于对照组。RTC的疗效优于ETC,明显优于TC。 The efficacies of high dosages of TC and its processed products were better than those of low dosages of the drugs. SS cells of various shapes, including cone-, spindle-, and ellipse-shaped SS cells, were observed. A large number of SS cells were found in the intestinal gland epithelium and intestinal lamina propria in the control group, and these cells were widely distributed in epithelial cells in the intestinal mucosa and intestinal gland epithelium in the experimental groups. Conclusion: This study indicates that TC and its processed products play an important role in inhibiting the secretion of SS to different degrees. The effect of the RTC at a dosage of 4.0 g•kg–1 BW is the best

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